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Biomarkers including HbA1c, fasting insulin, lipid profiles, and body composition measurements provide the quantitative feedback needed to determine whether the combined approach is producing the intended metabolic effects, whether adjustments to formulation or dosing are needed, and whether the balance between the two therapies remains appropriate as a woman's physiology evolves through and beyond the menopausal transition

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Moreover, cAMP, the first discovered secondary messenger, can regulate gene expression, protein activity and cell function by altering the level of cAMP, thereby influencing the processes of cell growth, metabolism, differentiation and apoptosis (52)

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